What was nothing more than an abandoned factory is now a complex hospital, with accompanying primary school, School of Nursing, a hydro-power company and other projects. The Hospital never closed, even in the terrible Amin and Obote years. The then President Obote threatened to bomb the hospital for supposedly caring for rebel fighters. In 1989, to meet the need of a growing number of national staff, the hospital opened its own primary school. Later, in the face of the growing AIDs crisis, it started its own child sponsorship programme, funded by the Dutch DORCAS programme in 1995 and Sponsor-An-Orphan in 1998.
The Kisiizi Hospital School of Nursing began in that year too, thereby ensuring a regular supply of new nurses to the expanding hospital, and to the region. Rehab and Mental Health Wards also began, and, in 2008, its links with Countess of Chester Hospital and Chester University came to life. It was a sign of the esteem in which Kisiizi is held, that in 2008 on the Golden Jubilee of the foundation of the hospital, not only the Diocesan Bishop attended but also the Archbishop, and a former patient – now the President of Uganda, attended the celebrations.